Protein Details: Aquaporin-5
Protein ID
ICDB_Pro_1197
Protein Name
Aquaporin-5
Gene Name
AQP5
Organism
Ovis aries (Sheep)
Length
265 amino acids
AlphaFoldDB
AF-Q866S3-F1-model_v4.pdb
Function
Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4; controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye; lung and in sweat glands (By similarity).
Sequence
MKKEVCSAAFLKAVFAEFLATLIFVFFGLGSALKWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAVFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAHWVFWVGPIVGAATAAIIYFYLLFPHSLSLSDRVAILKGTYEPDEDWEESQEERKKTMELTAH
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
RefSeq
NP_001009273.1